Azetidinones have been known to posses’ antibacterial activity, but recently some new pharmacological activities like antitubercular, carbonic anhydrase inhibitors, local anaesthetics, anti-inflammatory, antihelmintic, anticonvulsant and hypoglycemic activity, have been reported. They posses broad spectrum of activity and are in use as an analgesic agent since very long like few coxibs. Inspired by the above observations, synthesis of new derivatives of 3-(3-chloro-2-oxo-4-substituted phenylazetidin-1-yl)-2-isonicotinoyl-1,2-dihydropyrazol-5-one (3) and 2 - isonicotinoyl - 3 - (3-methyl - 2 - oxo - 4 - substituted phenylazetidin-1-yl)-1,2-dihydropyrazol-5-one (4) were synthesized using microwave as an alternate source of energy. Synthesis of effective COX-2 inhibitors was achieved by attachment of azetidinones with pyrazolones. Synthesized compounds were tested for their analgesic activity and it was found that activity of compound (4f) was comparable to that of the standard used. These compounds therefore, will be used as a prototype to computationally design similar analogues and synthesize those which score well so that, a potent analgesic compound can be obtained.
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